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可靠性 10

可靠度 3

可靠性灵敏度 3

多目标优化 3

失效概率 3

稳健设计 3

优化设计 2

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可靠性；维修性；保障性；指标量化 2

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Reliability guarantee framework for the Sichuan–Tibet Railway

《工程管理前沿（英文）》 2021年第8卷第4期页码 480-491 doi: 10.1007/s42524-021-0170-4

摘要： The Sichuan–Tibet Railway is facing extraordinary challenges in terms of construction, operation, and maintenance because of its extremely complicated natural environment and geological conditions. Consequently, countermeasures are necessary and urgent to ensure its safety and reliability in the whole life cycle. This study proposes a novel reliability framework to guarantee the ideal operation state of the Sichuan–Tibet Railway. Reliability application in many fields are summarized, including military equipment, rail locomotive, and railway engineering. Given the fact that the Sichuan–Tibet Railway is a complex giant system, Nine-Connotation was summarized (i.e., safety, inherent reliability, testability, maintainability, supportability, environmental adaptability, predictability, resilience, and durability) under the goal of optimizing the operational efficiency. On the basis of the concept of the Nine-Connotation and the understanding of reliability transmission mechanism, the framework of reliability for the Sichuan–Tibet Railway was established, which can facilitate a comprehensive and real-time evaluation of all situations with a clear hierarchy. The proposed framework is composed of a resilience management system, an integrated technology system, and a dynamic reliability assessment system. The pathway for its application on railway construction was developed in this study. The proposed framework can assist in well-informed decisions for the construction, as well as the operation of the Sichuan–Tibet Railway. On the basis of a top–down design concept for the first time, this study emphasizes the railway’s availability and validity to complete the assigned tasks as a whole, that is, operational efficiency. It also shows the reliability transmission and control mechanism of the railway’s giant complex system, innovating and establishing the management principle of great safety and great reliability over the life cycle.

关键词： Sichuan–Tibet Railway operational efficiency reliability guarantee Nine-Connotation implementation pathway

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Evaluation of the contract reliability for alternative infrastructure project delivery: a contract engineering

Bing WANG, Qingbin CUI, Shuibo ZHANG

《工程管理前沿（英文）》 2019年第6卷第2期页码 239-248 doi: 10.1007/s42524-019-0018-3

摘要： Governments at all levels are increasingly motivating the private sector to participate in infrastructure development using alternative project delivery methods to relieve financial burden. When designing contracts, governments usually offer incentives while requiring cost or time guarantee to balance project attractiveness to the private sector and fair protection of public interest. However, a practical and critical problem is how to properly design these provisions. Although previous studies have investigated the value of these provisions, a knowledge gap still exists with respect to methods of fairly and effectively designing such provisions. This study fills this gap by developing a methodology that analyzes the appropriateness of guarantee or warranty provisions for contracts. In this study, a contract reliability index is constructed, and a process of evaluating contract reliability is proposed. The New Mexico Highway 44 project, in which three warranty provision arrangements are investigated, is used as a case study to illustrate the analysis process. Results show that although a ceiling clause can effectively motivate the private sector to participate in the project, it sacrifices a significant amount of public benefits. By contrast, although a warranty option can protect public benefits, it cannot effectively incentivize the private sector. A combination of the ceiling clause and the warranty option will therefore result in improved contract provision design. The proposed methodology in this study is especially useful for governments in properly determining contract clauses in infrastructure development.

关键词： infrastructure development contract design contract reliability guarantee provision contract engineering

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Current status and prospects of reliability systems engineering in China

《工程管理前沿（英文）》 2021年第8卷第4期页码 492-502 doi: 10.1007/s42524-021-0172-2

摘要： This study provides a systematic overview of the advent and evolution of reliability systems engineering (RSE) in China, and the latest RSE development, that is, model-based RSE (MBRSE), is emphatically introduced. The establishment of the system architecture and conceptual models of MBRSE is first described. The fundamental theory and methodology of MBRSE are then elaborated, with a V-model as the core of this approach. The development of various MBRSE platforms and the effectiveness of their implementation over the past 30 years are presented. The prospective trends in the development of RSE in China are outlined.

关键词： reliability effectiveness model-based systems engineering reliability systems engineering

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Human reliability in maintenance task

Pacaiova HANA,

《机械工程前沿（英文）》 2010年第5卷第2期页码 184-188 doi: 10.1007/s11465-010-0002-4

摘要： Maintenance management requirements have another dimension in the present as in the past. Looking for the optimal tools of decision processing is hard. The current concepts have represented the integration of theoretical, technical, and management tools whose applications need actual modification. Technical measurements are expensive and take a long time/term, and it is hard to estimate the economical returns. This paper presents the concept of a maintenance management task and its function in preventing major accidents. The importance of considering the reliability of maintenance tasks and the method to reach it are also discussed in this paper.

关键词： maintenance risk assessment failure reliability prevention

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CAR T cells redirected against tumor-specific antigen glycoforms: can low-sugar antigens guarantee a

《医学前沿（英文）》 2022年第16卷第3期页码 322-338 doi: 10.1007/s11684-021-0901-2

摘要： Immune-based therapies have experienced a pronounced breakthrough in the past decades as they acquired multiple US Food and Drug Administration (FDA) approvals for various indications. To date, six chimeric antigen receptor T cell (CAR-T) therapies have been permitted for the treatment of certain patients with relapsed/refractory hematologic malignancies. However, several clinical trials of solid tumor CAR-T therapies were prematurely terminated, or they reported life-threatening treatment-related damages to healthy tissues. The simultaneous expression of target antigens by healthy organs and tumor cells is partly responsible for such toxicities. Alongside targeting tumor-specific antigens, targeting the aberrantly glycosylated glycoforms of tumor-associated antigens can also minimize the off-tumor effects of CAR-T therapies. Tn, T, and sialyl-Tn antigens have been reported to be involved in tumor progression and metastasis, and their expression results from the dysregulation of a series of glycosyltransferases and the endoplasmic reticulum protein chaperone, Cosmc. Moreover, these glycoforms have been associated with various types of cancers, including prostate, breast, colon, gastric, and lung cancers. Here, we discuss how underglycosylated antigens emerge and then detail the latest advances in the development of CAR-T-based immunotherapies that target some of such antigens.

关键词： cancer immunotherapy chimeric antigen receptor solid tumors tumor-associated antigen glycosylation O-glycans adoptive cell therapy

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An overview of the reliability metrics for power grids and telecommunication networks

《工程管理前沿（英文）》 2021年第8卷第4期页码 531-544 doi: 10.1007/s42524-021-0167-z

摘要： Power grids deliver energy, and telecommunication networks transmit information. These two facilities are critical to human society. In this study, we conduct a comprehensive overview of the development of reliability metrics for power grids and telecommunication networks. The main purpose of this review is to promote and support the formulation of communication network reliability metrics with reference to the development of power grid reliability. We classify the metrics of power grid into the reliability of power distribution and generation/transmission and the metrics of telecommunication network into connectivity-based, performance-based, and state-based metrics. Then, we exhibit and discuss the difference between the situations of the reliability metrics of the two systems. To conclude this study, we conceive a few topics for future research and development for telecommunication network reliability metrics.

关键词： reliability metrics power grids telecommunication networks

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System reliability and system resilience

《工程管理前沿（英文）》 2021年第8卷第4期页码 615-619 doi: 10.1007/s42524-021-0176-y

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Special issue: Reliability management of complex system

《工程管理前沿（英文）》 2021年第8卷第4期页码 477-479 doi: 10.1007/s42524-021-0175-z

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Reliability design method for steam turbine blades

SHI Jinyuan

《能源前沿（英文）》 2008年第2卷第4期页码 363-368 doi: 10.1007/s11708-008-0073-7

摘要： Based on theories of probability and statistics, and taking static stresses, dynamic stresses, endurance strength, safety ratios, vibration frequencies and exciting force frequencies of blades as random variables, a reliability design method for steam turbine blades is presented. The purport and calculation method for blade reliability are expounded. The distribution parameters of random variables are determined after analysis and numerical calculation of test data. The fatigue strength and the vibration design reliability of turbine blades are determined with the aid of a probabilistic design method and by interference models for stress distribution and strength distribution. Some blade reliability design calculation formulas for a dynamic stress design method, a safety ratio design method for fatigue strength, and a vibration reliability design method for the first and second types of tuned blades and a packet of blades on a disk connected closely, are given together with some practical examples. With these methods, the design reliability of steam turbine blades can be guaranteed in the design stage. This research may provide some scientific basis for reliability design of steam turbine blades.

关键词： design reliability force probability purport reliability design

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水下隧道衬砌结构服役安全及其保障对策思考

何川,刘四进,张玉春,封坤

《中国工程科学》 2017年第19卷第6期页码 44-51 doi: 10.15302/J-SSCAE-2017.06.007

摘要：

本文从设计施工、环境侵蚀、突发自然灾害及突发事故灾害四个方面，分析了我国隧道衬砌结构安全所面临的问题；对上海地区黄浦江越江隧道和地下交通隧道等水下隧道工程进行了调查，重点分析了我国在役水下隧道衬砌结构服役的现状。并基于此，为有效保障隧道结构全寿命周期过程中的安全服役性能，及预留隧道结构长寿命有效条件，从隧道建设、结构性能退化、自然灾害、突发事故灾害等方面入手，探寻我国水下隧道结构的长寿命安全保障对策，以确保在隧道的全寿命周期内乃至长寿命要求下结构的安全服役性能。研究成果可为保障我国水下隧道等重大隧道结构的长寿命安全提供参考。

关键词：水下隧道服役安全安全保障对策长寿命结构病害

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A reliability growth model for 300?MW pumped-storage power units

Jinyuan SHI , Yu YANG , Zhicheng DENG ,

《能源前沿（英文）》 2009年第3卷第3期页码 337-340 doi: 10.1007/s11708-009-0032-y

摘要： A reliability growth model for pumped-storage power units is presented. Ways for estimating and fitting on checking the model’s parameters are given together with analysis results concerning the reliability growth of 300MW pumped-storage power units. On site operation, reliability data show that the reliability growth model conforms to rules of reliability growth tendency. Analysis results of reliability growth indicate that measures taken for improving maintenance and operation by the pumped-storage power companies are effective and that the reliability of the 300MW pumped-storage power units exhibits a rising tendency.

关键词： pump-storage power unit availability reliability growth reliability prediction

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An exploratory study for predicting component reliability with new load conditions

Zhengwei HU, Xiaoping DU

《机械工程前沿（英文）》 2019年第14卷第1期页码 76-84 doi: 10.1007/s11465-018-0522-x

摘要： Reliability is important to design innovation. A new product should be not only innovative, but also reliable. For many existing components used in the new product, their reliability will change because the applied Loads are different from the ones for which the components are originally designed and manufactured. Then the new reliability must be re-evaluated. The system designers of the new product, however, may not have enough information to perform this task. With a beam problem as a case study, this study explores a feasible way to re-evaluate the component reliability with new Loads given the following information: The original reliability of the component with respect to the component Loads and the distributions of the new component Loads. Physics-based methods are employed to build the equivalent component limit-state function that can predict the component failure under the new Loads. Since the information is limited, the re-evaluated component reliability is given by its maximum and minimum values. The case study shows that good accuracy can be obtained even though the new reliability is provided with the aforementioned interval.

关键词： reliability component failure mode prediction random variable

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Principle of maximum entropy for reliability analysis in the design of machine components

Yimin ZHANG

《机械工程前沿（英文）》 2019年第14卷第1期页码 21-32 doi: 10.1007/s11465-018-0512-z

摘要： We studied the reliability of machine components with parameters that follow an arbitrary statistical distribution using the principle of maximum entropy (PME). We used PME to select the statistical distribution that best fits the available information. We also established a probability density function (PDF) and a failure probability model for the parameters of mechanical components using the concept of entropy and the PME. We obtained the first four moments of the state function for reliability analysis and design. Furthermore, we attained an estimate of the PDF with the fewest human bias factors using the PME. This function was used to calculate the reliability of the machine components, including a connecting rod, a vehicle half-shaft, a front axle, a rear axle housing, and a leaf spring, which have parameters that typically follow a non-normal distribution. Simulations were conducted for comparison. This study provides a design methodology for the reliability of mechanical components for practical engineering projects.

关键词： machine components reliability arbitrary distribution parameter principle of maximum entropy

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基于全寿命劣化分析的海底盾构隧道管片安全保障对策研究

刘四进,何川,孙齐,封坤

《中国工程科学》 2017年第19卷第6期页码 52-60 doi: 10.15302/J-SSCAE-2017.06.008

摘要：

管片接头是海底盾构隧道衬砌结构的薄弱环节，在海水的高压力与腐蚀环境的持续耦合作用下，其劣化性能严重影响整个海底盾构隧道衬砌结构的安全。本文在分析既有管片接头侵蚀劣化研究成果的基础上，引入隧道服役时间因素，建立可实现海水压力渗透与氯离子侵蚀的管片接头全寿命侵蚀劣化分析模型，分析了全寿命周期（100年）内海底隧道管片接头的渐进式侵蚀劣化规律，重点研究了海水压力与氯离子浓度对管片接头侵蚀劣化及钢筋锈蚀的影响，并基于全寿命周期内的侵蚀劣化分析，提出保障海底盾构隧道管片衬砌结构长期安全的最经济、最合理的对策。

关键词：盾构隧道安全保障劣化分析离子侵蚀管片接头